Williams血液学（第9版）(英文版） 下载 pdf 百度网盘 epub 免费 2025 电子版 mobi 在线

《Williams血液学》是血液学领域的经典之作，涵盖了血液学的所有方面，介绍了患者临床评估、血液病的分子学和细胞学基础，并具体阐述了红细胞疾病、粒细胞和单核细胞疾病、淋巴细胞和浆细胞疾病、髓系肿瘤性疾病、淋巴组织疾病、止血和血栓、输血医学等内容。第9版在第8版的基础上做了大篇幅的修改和更新，以反映血液学领域的*进展。新增加了表观遗传学和基因组学、血液肿瘤细胞的新陈代谢和肝素诱导性血小板减少症等内容。本书是血液科临床医生、实习生、血液学研究人员必不可少的案头佳作，也是学习血液学专业英语的工具书。

简  目

Contributors

Preface

PART IClinical Evaluation of the Patient

PARTII  TheOrganization of the LymphohematopoieticTissues

PARTIII  EpochalHematology

PARTIV  Molecular and CellularHematology

PARTV  TherapeuticPrinciples

PARTVI  The Erythrocyte

PARTVII  Neutrophils,Eosinophils,Basophils, and Mast Cells

PARTVIII  Monocytes and Macrophages

PARTIX  Lymphocytes and Plasma Cells

PARTX  MalignantMyeloid Diseases

PARTXI  MalignantLymphoid Diseases

PARTXII  Hemostasis andThrombosis

PARTXIII  Transfusion Medicine

Index

v 

目  录

Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .ix

Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xxi

PART I

ClinicalEvaluation of the Patient

1.InitialApproachto the Patient:HistoryandPhysicalExamination

2.Examinationof Blood Cells

3.ExaminationofTheMarrow

4.ConsultativeHematology

PART II

TheOrganization of the LymphohematopoieticTissues

5.Structureof the Marrowand the HematopoieticMicroenvironment

6.The Organization and StructureofLymphoid Tissues

PART III

Epochal Hematology

7.Hematologyof the FetusandNewborn

8.HematologyduringPregnancy

9.Hematology in OlderPersons

PART IV

Molecular and CellularHematology

10.Genetic PrinciplesandMolecular Biology

11.Genomics

12.Epigenetics

13.Cytogeneticsand Genetic Abnormalities

14.MetabolismofHematologicNeoplastic Cells

15.ApoptosisMechanisms:Relevanceto the HematopoieticSystem

16.Cell-CycleRegulationandHematologicDisorders

17.SignalTransductionPathways

18.HematopoieticStem Cells, Progenitors,andCytokines

19.TheInflammatory Response

20.InnateImmunity

21.Dendritic Cells andAdaptiveImmunity

PARTV

TherapeuticPrinciples

22.PharmacologyandToxicityofAntineoplastic Drugs

23.Hematopoietic Cell Transplantation

24.Treatment of InfectionsinTheImmunocompromisedHost

25.AntithromboticTherapy

26.Immune Cell Therapy

27.VaccineTherapy

28.TherapeuticApheresis:Indications,Efficacy,andComplications

29.Gene TherapyforHematologicDiseases

30.RegenerativeMedicine:MultipotentialCellTherapy for

TissueRepair

PARTVI

The Erythrocyte

31.StructureandCompositionof the Erythrocyte

32.Erythropoiesis

33.Erythrocyte Turnover

34.ClinicalManifestations and Classification ofErythrocyteDisorders

35.AplasticAnemia:Acquiredand Inherited.

36. Pure Red Cell Aplasia

37.  Anemia of ChronicDisease

38.  The Congenital DyserythropoieticAnemias

39.  Paroxysmal Nocturnal Hemoglobinuria

40.  ParoxysmalNocturnalHemoglobinuria

41.  Folate,Cobalamin,andMegaloblasticAnemias

42.IronMetabolism

43.Iron Deficiency andOverload

44.  Anemia Resulting fromOtherNutritionalDeficiencies

45.  Anemia AssociatedwithMarrowInfiltration

46.  Erythrocyte MembraneDisorders

47.  Erythrocyte Enzyme Disorders

48.  TheThalassemias: Disorders of GlobinSynthesis

49.  DisordersofHemoglobinStructure:Sickle CellAnemiaandRelatedAbnormalities

50.  Methemoglobinemiaand Other Dyshemoglobinemias

51.  FragmentationHemolyticAnemia

52.  Erythrocyte Disordersas a ResultofChemicalandPhysicalAgents

53.  HemolyticAnemiaResultingfromInfectionswithMicroorganisms

54.  HemolyticAnemiaResultingfromImmuneInjury

55.  AlloimmuneHemolytic Disease of the FetusandNewborn

56.  HypersplenismandHyposplenism

57.  Primary and Secondary Erythrocytoses

58.ThePorphyrias

59.PolyclonalandHereditarySideroblasticAnemias

PARTVII

Neutrophils,Eosinophils,Basophils, and Mast Cells

60. StructureandCompositionofNeutrophils,Eosinophils,andBasophils

61. Production,Distribution,andFateofNeutrophils

62. EosinophilsandRelatedDisorders

63. Basophils,Mast Cells, andRelatedDisorders

64. Classificationand Clinical ManifestationsofNeutrophilDisorders

65. NeutropeniaandNeutrophilia

66. DisordersofNeutrophilFunction

PARTVIII

Monocytes and Macrophages

67. Structure,Receptors,andFunctionsofMonocytesandMacrophages

68. Production,Distribution,andActivationofMonocytesandMacrophages

69. Classificationand ClinicalManifestationsof DisordersofMonocytesandMacrophages

70. MonocytosisandMonocytopenia

71. Inflammatory andMalignantHistiocytosis

72.  Gaucher Disease andRelatedLysosomalStorageDiseases

73.  PART IX

Lymphocytes and Plasma Cells

73.The StructureofLymphocytes andPlasma Cells

74.LymphopoiesisFunctionsof B LymphocytesandPlasma Cells inImmunoglobulinProduction

75.  Functionsof T Lymphocytes:T-CellReceptorsforAntigen

76.  FunctionsofNaturalKiller Cells

77.  Classificationand Clinical ManifestationsofLymphocyteandPlasma Cell Disorders

79.LymphocytosisandLymphocytopenia

80.Immunodeficiency Diseases

81.HematologicManifestationsofAcquiredImmunodeficiencySyndrome

82.MononucleosisSyndromes

PART X

MalignantMyeloid Diseases

83.Classification and ClinicalManifestationsoftheClonalMyeloidDisorders

84.PolycythemiaVera

85.EssentialThrombocythemia

86.Primary Myelofibrosis

87.MyelodysplasticSyndromes

88.AcuteMyelogenousLeukemia

89.ChronicMyelogenousLeukemiaandRelatedDisorders

PART XI

MalignantLymphoid Diseases

90.ClassificationofMalignantLymphoid Disorders

91.AcuteLymphoblasticLeukemia

92.ChronicLymphocyticLeukemia

93.Hairy Cell Leukemia

94.LargeGranularLymphocyticLeukemia

95.General ConsiderationsforLymphomas:Epidemiology,Etiology,Heterogeneity,and Primary Extranodal Disease

96.PathologyofLymphomas.

97.HodgkinLymphoma

98.Diffuse Large B-Cell Lymphoma andRelated Diseases

99.FollicularLymphoma

100.Mantle Cell Lymphoma

101.MarginalZone B-Cell Lymphomas

102.BurkittLymphoma

103.CutaneousT-CellLymphoma(MycosisFungoidesandSézarySyndrome)

104.MatureT-CellandNaturalKiller Cell Lymphomas

105.Plasma Cell Neoplasms: General Considerations

106.EssentialMonoclonalGammopathy

107.Myeloma.

108.ImmunoglobulinLight-ChainAmyloidosis

109.Macroglobulinemia.

110.Heavy-Chain Disease

PART XII

Hemostasis andThrombosis

111.Megakaryopoiesis andThrombopoiesis

112.PlateletMorphology,Biochemistry,and Function

113.Molecular Biology andBiochemistryof theCoagulationFactorsandPathwaysofHemostasis

114.ControlofCoagulationReactions

115.VascularFunction in Hemostasis

116.Classification, Clinical Manifestations, andEvaluationofDisordersofHemostasis

117.Thrombocytopenia

118.Heparin-Induced Thrombocytopenia

119.ReactiveThrombocytosis

120.HereditaryQualitativePlateletDisorders

121.AcquiredQualitativePlateletDisorders

122.TheVascularPurpuras

123. Hemophilia A andHemophilia B

124. InheritedDeficiencies of Coagulation FactorsII,V,V VIII, VII, X, XI, and XII

125. Hereditary Fibrinogen Abnormalities

126. von Willebrand Disease

127. Antibody-Mediated Coagulation FactorDeficiencies

128. HemostaticAlterations in Liver Disease andLiverTransplantation

129. DisseminatedIntravascularCoagulation

130.HereditaryThrombophilia

131. The AntiphospholipidSyndrome

132. Thrombotic Microangiopathies

133.VenousThrombosis

134. Atherothrombosis: Disease Initiation,Progression,andTreatment

135. Fibrinolysis andThrombolysis

PART XIII

Transfusion Medicine

136. Erythrocyte AntigensandAntibodies

137. Human Leukocyte andPlateletAntigens

138. Blood Procurementand Red Cell Transfusion

139. Preservationand Clinical UseofPlatelets

Index

考杉斯基(Kaushansky)博士是纽约州立大学石溪分校健康科学院的高级副总裁，同时担任该校医学院院长的职务。考杉斯基(Kaushansky)博士是全球知名的血液学专家，发表过多篇有影响力的著作。担任《Willians血液学》第8版、第9版的主编。

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编辑推荐

经典名著  《Williams血液学》是血液学领域公认的经典之作，经过多次修订，指导了一代又一代的临床医生、生物学研究者和众多学科的实习生。作者们均是各自领域的学术带头人，他们的基础和临床成果得到了国际广泛认可。

内容全面  共139章，涵盖了血液学的所有方面。前半部分讨论了患者临床评估、血液病的分子学和细胞学基础，后半部分具体阐述了红细胞疾病、粒细胞和单核细胞疾病、淋巴细胞和浆细胞疾病、髓系肿瘤性疾病、淋巴组织疾病、止血和血栓，以及输血医学。包含彩图1300余幅。

与时俱进  《Williams血液学（第9版）》在基础科学、转换病理生理学和临床实践方面做了大篇幅的修改和更新，以反映血液学领域*的研究进展。

印刷精美   全书彩色印刷，包含大量极具诊断价值的细胞形态学图片，使阅读和查找更加直观、方便。

前言

前  言PREFACE

The first edition of

Williams Hematology (né Hematology)

was publishedin 1972. This, our 9th edition, will represent our continued efforts over nearly one-half century to provide the most current concepts of the pathophysiology and treatment of hematologic diseases.

The rate of growth in our understanding of diseases of blood cells and coagulation pathways provides a challenge for editors of a comprehensive textbook of hematology. The sequencing of individual genomes, analysis of the “dark DNA” and noncoding RNAs, advances in knowledge in proteomics, metabolomics, and other “-omics” fields, as applied to hematologic disorders, have accelerated the understanding of the pathogenesis of the diseases of our interest. The rate at which basic knowledge in molecular and cellular biology and immunology has been translated into improved diagnostic and therapeutic methods is equally impressive. Specific molecular targets for therapy in several hematologic disorders have become reality, and it is not hyperbole to state that hematology is the poster child for the rational design of therapeutics applicable to other fields of medicine.

This edition of

Williams Hematology

includes changes designed tofacilitate ease of access to information, both within the book and its associated links, and has been modestly reorganized to reflect our greater understanding of the origins of hematologic disorders. Each chapter has been revised or rewritten to provide current information. Four new chapters have been added and other notable changes have been made. Chapter 4 “Consultative Hematology” is new to this edition. The chapter “Epigenetics and Genomics” has been divided into separate chapters to reflect the growth of knowledge in those disciplines. Chapter 14, “Metabolism of Hematologic Neoplastic Cells” is new, as this topic has become the basis of multiple potential drug targets for hematologic disease. A section on “Autophagy” has been added to Chap 15 “Apoptosis Mechanisms: Relevance to the Hematopoietic System,” as the topic is becoming increasingly important for understanding of the physiology of blood cell development; and an independent chapter “Heparin-Induced Thrombocytopenia” (Chap 118) has been created to reflect both its pathophysiologic and clinical importance. Recognizing that at the heart of diagnostic hematology is blood and marrow cell morphology, we have continued our incorporation of informative color images of the relevant disease topics in each chapter, allowing easy access to illustrations of cell morphology important to diagnosis.

The 9th edition of Williams Hematology is also available online,as part of the excellent www.accessmedicine.com website. With direct links to a comprehensive drug therapy database and to other important medical texts, including Harrison’s Principles of Internal Medicine and Goodman and Gilman’sof Williams Hematology also includes PubMed links to journal articlescited in the references.

In addition, Williams Manual of Hematology will be revised to reflect the diagnostic and therapeutic advances incorporated in the 9th edition of Williams Hematology. The convenient Manual features the most clinically salient content from the parent text, and is useful in time-restricted clinical situations. The Manual will be available for iPhone™ and other mobile formats.

The readers of the 9th edition of Williams Hematology will note a“changing of (some of) the guard” of our editorial group; Drs. Marcel Levi (a member of the 8th edition of Williams Manual of Hematology editorial group), Oliver Press, Linda Burns, and Michael Caligiuri have joined continuing editors Drs. Kenneth Kaushansky, Marshall Lichtman, and Josef Prchal in the 9th edition.

The production of this book required the timely cooperation of 101 contributors for the production of 139 chapters. We are grateful for their work in providing this comprehensive and up-to-date text. Despite the growth of both basic and clinical knowledge and the passion that each of our contributors brings to the topic of their chapter, we have been able to maintain the text in a single volume through scrupulous attention to chapter length.

Each editor has had expert administrative assistance in the management of the manuscripts for which they were primarily responsible. We thank Susan Madden in Salt Lake City, Utah; Nancy Press and Deborah Lemon in Seattle, Washington; and Annie Thompson, Rebecca Posey, and Kimberly Morley in Columbus, Ohio for their very helpful participation in the production of the book. Special thanks go to Susan Daley in Rochester, New York, and Marie Brito in Stony Brook, New York, who were responsible for coordinating the management of 139 chapters, including many new figures and tables, and managing other administrative matters, a challenging task that Ms. Daley and Ms. Brito performed with skill and good humor.

Kenneth Kaushansky

Marshall A. Lichtman Joseph T. Prchal

Marcel Levi

Oliver W. Press

Linda J. Burns

书籍介绍

权威、全面、全新、全彩

举世公认的血液学经典著作

基础与实践

实验与临床

诊断与鉴别

………………

※编辑推荐※

☆经典名著 ： 《Williams血液学》是血液学领域公认的经典之作，经过多次修订，指导了一代又一代的临床医生、生物学研究者和众多学科的实习生。作者们均是各 自领域的学术带头人，他们的基础和临床成果得到了国际广泛认可。

☆内容全面 ：共139章，涵盖了血液学的所有方面。前半部分讨论了患者临床评估、血液病的分子学和细胞学基础，后半部分具体阐述了红细胞疾病、粒细胞和单核细胞疾病、淋巴细胞和浆细胞疾病、髓系肿瘤性疾病、淋巴组织疾病、止血和血栓，以及输血医学。包含彩图1300余幅。

☆与时俱进 ：《Williams血液学（第9版）》在基础科学、转换病理生理学和临床实践方面做了大篇幅的修改和更新，以反映血液学领域最新的研究进展。

☆印刷精美 ： 全书彩色印刷，包含大量极具诊断价值的细胞形态学图片，使阅读和查找更加直观、方便。

………………

※内容简介※

《Williams血液学》是血液学领域的经典之作，涵盖了血液学的所有方面，介绍了患者临床评估、血液病的分子学和细胞学基础，并具体阐述了红细胞疾病、粒细胞和单核细胞疾病、淋巴细胞和浆细胞疾病、髓系肿瘤性疾病、淋巴组织疾病、止血和血栓、输血医学等内容。

第9版在第8版的基础上做了大篇幅的修改和更新，以反映血液学领域的最新进展。新增加了表观遗传学和基因组学、血液肿瘤细胞的新陈代谢和肝素诱导性血小板减少症等内容。

本书是血液科临床医生、实习生、血液学研究人员必不可少的案头佳作，也是学习血液学专业英语的工具书。